Epigenetic regulation is achieved by equilibrium between DNA methylation and demethylation which regulates gene expression, genome stability, and genomic imprinting. DNA methylation marks (5-methylcytosine, 5-mC) are primarily found on the CpG sites of gene promoter regions. Cytosine is converted to 5-mC via DNA methyltransferase (DNMT), while a family of ten-eleven translocation dioxygenases (TET) catalyze local demethylation per an Fe(II)/alpha-ketoglutarate-dependent oxidation cascade on the C-5 position of 5-mC.

Background: This study sought to investigate runners’ experiences of public harassment in the United States, specifically the association between gender and sexual orientation and harassment experiences.

Methods: Adult runners living in the United States (N = 1645) completed an online survey distributed through social media, running organizations' email lists, and participant referrals. Survey data reported here include forms of harassment experienced over the lifetime as well as participant demographics.

The influence of cover crops on soil moisture and temperature varies depending on soil type, climate, and management. Cover crops are an important element of organic crop production due to their ability to maintain a beneficial amount of plant-available soil nitrogen while providing additional soil health benefits. They have potential to increase soil’s water holding capacity or take up available water in the soil depending on conditions.

With the spread of the COVID-19 virus leading to a worldwide pandemic, the prevention of biological invasion has become increasingly important. Knowledge on psychological and behavioral reactions from the COVID-19 pandemic can help manage future biosafety and biosecurity reactions and behaviors, potentially altering courses of future zoonotic diseases, epidemics, and pandemics. Generally, personality traits play a role in creating safe environments (Lee & Dalal, 2016).

Ophthalmic complications, including corneal clouding, retinopathy, and glaucoma, are common in patients with Mucopolysaccharidosis Type I (MPS I). Although previous research has shown that glycosaminoglycans (GAGs) accumulate in retinal tissue disrupting retinal function in patients with MPS I, the development timetable for retinal pathophysiology remains unclear. The purpose of this project was to visualize and measure GAG accumulation in a mouse model for MPS I.

Junctophilin-2 (JPH2) is a junctional membrane-binding protein that plays a role in connecting the sarcoplasmic reticulum to the plasma membrane in cardiac cells. While there are four JPH isoforms, JPH2 is the primary isoform in cardiac muscle cells. JPH2 regulates the sarcoplasmic ryanodine receptor calcium (Ca2+) channels (RyR2) and T-tubule formation/structure. The JPH2 protein is composed of several repeating MORN motifs linked by a joining region, followed by an alpha helical and a divergent region.

Early Childhood and Family Education (ECFE) is a program offered by the Minnesota Department of Education ("Early Childhood Family Education," n.d.). It provides parenting and early childhood education for families with children from birth to age five, although some programs are offered for children through third grade. Emphasis is placed on helping caregivers ECFE classes occur in classroom settings, home visits, and online meetings, with the occasional use of community settings.

Community and school settings have become more culturally and racially diverse. Therefore, students have more chances to make friends with others of various ethnicities and races in school. This poster will focus on the relationship between adolescents’ multicultural friendships and their participation in civic engagement. Participants were ninth-graders (N=439) from a midwestern city and they completed a survey in class. Students identified themselves as female (47.4%), male (44.6%), and others (8%).

While the adult mammalian heart has limited regenerative potential, the neonatal mouse heart has a remarkable regenerative capacity. Therefore, we focused on defining new factors and mechanisms that could enhance repair and regeneration in the adult mouse heart. FOXK1 is a transcription factor that regulates cell cycle kinetics, myogenic stem cell proliferation and skeletal muscle regeneration. During development, its expression is restricted to progenitors, somites and the heart. However, its role in the neonatal heart and regeneration is unknown and warrants investigation.