Under changing conditions of precipitation due to climate change and possible shifts in precipitation sourcing, having a baseline of precipitation sourcing for regions across the U.S. will become increasingly important. This baseline will be especially important for winter precipitation in snowfall regions such as the upper Midwest U.S. because snowpack is a crucial water source for rivers, lakes, aquifers and drinking water systems across the country.
Background: Pulmonary arterial hypertension (PAH) is a fatal disease with a median survival of only 5-7 years. Increased expression of Glut1 and Glut4 occurs in the RV in PAH, but the upstream regulators of these proteins are unknown. The With-no-Lysine (WNK) kinase-1 promotes expression of Glut1/4 in skeletal muscle, but its regulation in the RV in PAH is unexplored. Furthermore, the relationship between WNK1, Glut1, Glut4, and protein O-GlcNACylation (POGN) in the RV are unknown.
“We’re Coming for You”: Challenging the Virtue Ethic of Amateurism. How the Passage of California Senate Bill 206 is Changing the Face of Intercollegiate Athletics. Authors: Eddie G. Walker II, Ph.D. & Gregory Johnson Institution: University of Minnesota Crookston This proposed study will focus on how student-athletes can benefit from a union (not for payment) but for protection and security. Most importantly, athletes take risks that can be detrimental to their futures in competing in college athletics.
The advancement of 3D bioprinted models has the potential to improve research by replacing animal models and to support regenerative medicine by minimizing organ transplant waitlists, diminishing the risk of organ transplant rejection, and curing a variety of degenerative diseases. The Ogle Lab has applied 3D bioprinting in order to generate complex cardiac mimics using human induced pluripotent stem cells; however, researchers have experienced challenges with the leakiness of 3D bioprinted structures, as well as the reproducibility and resolution of printing.
G protein-coupled receptors (GPCRs) play a key role in cardiac function. Abnormalities in GPCRs result in a wide variety of cardiovascular conditions, including heart failure. In addition, we know that inflammation leading to fibrosis is associated with the development of heart failure. Understanding GPCR signaling pathways and their potential roles in inflammation and heart failure could lead to the development of novel strategies to treat heart failure. The convention is that GPCRs are located on the cell surface.
A three-dimensionally ordered macroporous (3DOM) material was synthesized from a Pechini solution containing zinc, cerium and aluminum nitrates with ethylene glycol and citric acid. The solution was infiltrated into two different polymeric colloidal crystal templates. Both templates were made out of poly(methyl methacrylate), although one used a potassium persulfate initiator and had a sphere size of 350 nm, while the other used 2,2’-azobis(2-methylpropionamidine) dihydrochloride as an initiator and had a sphere size of 300 nm.
Children in foster care have complex health concerns that often interplay with their childhood experiences, environment and access to care. Studies suggest that foster care youth are at increased risk for mental health and physical disabilities. Although traditionally associated with insufficient bone development, the implications of vitamin D deficiency are broadening to behavioral, neurodevelopmental, and psychological phenomena including depressive symptoms and clinical depression which may be a factor for this population.
L1 cell adhesion molecules (L1CAMs) are conserved immunoglobulin-like transmembrane glycoproteins that have important roles in nervous system development through cell-to-cell adhesion. L1CAMs are integral to nervous system functioning and are involved in axon guidance, synaptic development, and synaptic function. Mutations of L1CAM genes are associated with disorders such as X-linked L1 syndrome. Siblings with the same L1CAM alleles can have different phenotypes, which suggests that modifier genes interact with L1CAM genes to contribute to symptoms.
Death can be an uncomfortable thing to talk about and explore due to its somber mood. However, national data analysis has been done to conclude different trends within multiple transition choices after death. This individual research project looks at various demographics within the state of Minnesota from 2013 to 2018 and analyzes the correlations between them along with distributions within the population.
The purpose of this study was to examine the effects of ADHD course and age of onset on brain outcomes. Adult-onset ADHD is a recent development in the field, and whether brain deviations found in childhood-onset ADHD are also found for adult-onset ADHD has not yet been examined. The four groups we examined were childhood-onset remitted, childhood-onset persistent, adult-onset, and no ADHD.