Identification of Metformin's Chemical Mechanism on its Effect Toward Liver's Gluconeogenesis Process Using Computational Chemistry
We proposed to investigate on the mechanism of current Type-II treatment metformin’s reaction pathway in gluconeogenesis process on human liver. Gluconeogenesis is a process of synthesizing glucose from consuming ATP and generate the equal amount in return. For diabetes patients. too much glucose present in the body system would become overloaded for the insulin to process.The key characteristic of metformin is that it would not increase the insulin level of the patient’s body, which makes it a more compatible medication for Type-II patients. However, because the reaction path for how metformin reacts in our human body along with the mechanism of the medicine is remained undiscovered, the possible side effect study in Metformin is not completed. Despite the effect of metformin and the possible outcome is well known, the actual chemical reaction pathway and its mechanism that led to certain results remains unknown. Therefore, we propose to discover the reaction path for Metformin in liver and for the gluconeogenesis process. The hypothesis for this research was that metformin, when absorbed by the liver, could suppress the ATP production, and decrease the concentration of glucose produced by this process.